sjd-phys-math sjd-chemistry sjd-med-pharma sjd-biology : biologie chemie pharmazie physik (doktorarbeit): structure and function of membrane intrinsic receptors

SCIENCE-JOBS-DE Stellenausschreibung
 
Fachgebiete: Biologie Chemie Pharmazie Physik
Thema:  Doktorarbeit: Structure and function of membrane intrinsic receptors
Ansprechpartner: Prof. Wolfram Saenger
Antwort an:  saenger@chemie.fu-berlin.de
Institution: Chemistry and Biochemistry/Crystallography
Ort: 14195 Berlin, Takustr. 6
 
We are working on membrane intrinsic receptors in collaboration with several biochemically oriented groups in berlin. The receptors are expressed heterologously, purified and crystallized. X-ray diffraction data of the crystals will be collected at the Berlin synchrotron BESSY, processed and the structures determined by state of the art methods.
 
Methoden:
Purification of receptors by chromatographic methods, protein X-ray crystallography, solution of the phase problem by heavy atom methods employing anomalous dispersion or molecular replacement, determination of the structures under guidance of experienced postdocs.
 
Anfangsdatum: 1. Februar 2008
 
geschätzte Dauer: 3 years
 
Bezahlung: 2/3 BAT IIa
 
Veröffentlichungen:
M. Hülsmeyer et al., Dual, HLA-B27 Subtype-dependent Conformation of a Self-peptide, J. Exp. Med 199, 271-281, 2004.
W. Weihofen et al., Crystal Structure of CD26/Dipeptidylpeptidase IV in Complex with Adenosine Deaminase Reveals a Highly Amphiphilic Interface, J. Biol. Chem. 279, 43330-43335 (2004).
 
Homepage: http://userpage.chemie.fu-berlin.de/~sfb449/
 
We are looking for a highly motivated person with good background in biochemistry, biophysics or related sciences.
 
SCIENCE-JOBS-DE